Lizzo shut down rumors her dramatic body transformation was due to Ozempic. The singer said her weight loss was the result of "five months of weight training and calorie deficit."

While both berberine and Ozempic may lead to weight loss, they are very different things. It’s “inaccurate and misleading” to call berberine “nature’s Ozempic,” Dr. Ali says, noting that they work differently in the body and have very different weight loss results.

For significant weight loss, Zepbound may be the better option. If you have Type 2 diabetes and are looking for a dual approach to managing weight and the disease, Ozempic would likely be more suitable. Ultimately, talk to your doctor about health needs, financial situation and personal weight loss goals.