The doctors of Grey Sloan Memorial continue to experience personal and medical drama in Season 21 of Grey's Anatomy. The long-running series will return on Sept. 26 on ABC at 10 p.m. EDT. Catherine Fox (Debbie Allen),

Jo Wilson (Camilla Luddington) is also facing her own challenges, grappling with her pregnancy while keeping the news from Link (Chris Carmack)

The Grey's Anatomy Season 21 trailer teases Jesse Williams' return as Jackson Avery while more trouble is brewing at Grey Sloan

Tensions are running high, and some familiar faces are back in the first look at "Grey's Anatomy" season 21. The teaser features the return of actress Kali Rocha, who played Sydney Heron in guest and recurring capacity from season 2 to 4,

Jesse Williams makes a return to the hit medical drama "Grey's Anatomy," and he's joined by another familiar face. Ellen Pompeo, who plays Dr. Meredith Grey will also guest star for seven episodes during the 21st season.

Grey's Anatomy fans need season 21, stat - especially after that spring cliffhanger where multiple doctors were fired. "I'm really excited for fans to see how we get out of the end of last season," Grey's showrunner Meg Marinis told Entertainment Weekly in September 2024.

Grey’s Anatomy season 21 will premiere on Sept. 26, and an exclusive trailer teased lots of drama in store for Ellen Pompeo’s Meredith, as well as seeing two beloved characters making their return.

Grey’s Anatomy is back with new patients and drama among the characters in season 21 of the medical show. With the trailer released by the ABC Network on Thursday, September 19, the fans got a sneak peek into what could be expected of the episodes that are set to be released by the end of the month.