The 49ers are likely to be without George Kittle, Christian McCaffrey and Deebo Samuel for Sunday's game at the Rams.

Greg Papa joins "49ers Talk" host Matt Maiocco and discusses if 49ers wide receiver Brandon Aiyuk will step up in Rams ...

Speaking to NBC Sports Bay Area's Greg Papa on "49ers Game Plan," Kyle Shanahan explained why the offense won't change ...

San Francisco 49ers' George Kittle is listed as doubtful for Sunday's game against the Rams. He joins Christian McCaffrey and ...

The 49ers revealed their status reports Friday for their injured players ahead of Sunday’s visit to the Los Angeles Rams.

San Francisco 49ers running back Christian McCaffrey will be eligible off the injured reserve after Week 6, but could still miss a pivotal Week 7 Super Bowl rematch with the Kansas City Chiefs.

SANTA CLARA, Calif. (AP) — The San Francisco 49ers will likely be without All-Pro tight end George Kittle for Sunday's game ...

The 49ers revealed their status reports Friday for their injured players ahead of Sunday’s visit to the Los Angeles Rams.

Injuries have been running amock for the San Francisco 49ers this season. It started with running back Christian McCaffrey ...

San Francisco 49ers quarterback Brock Purdy will be tested in the coming weeks with the absence of key offensive weapons.

Injuries are piling up for the 49ers as they gear up for a critical showdown against the Rams. Head coach Kyle Shanahan ...

San Francisco 49ers star tight end George Kittle is doubtful for Sunday's game at the Los Angeles Rams due to a hamstring ...